THE WOBBLER MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) DISPLAYS HIPPOCAMPAL HYPEREXCITABILITY, AND REDUCED NUMBER OF INTERNEURONS, BUT NO PRESYNAPTIC VESICLE RELEASE IMPAIRMENTS.

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease.It is a fatal degenerative disease, best recognized for its debilitating neuromuscular effects.ALS however also induces cognitive impairments in as many as 50% of affected individuals.Moreover, many ALS patients demonstrate cortical hyperexcitability, which has

The polyphagous shot hole borer and Kuroshio shot hole borer, two members of the Euwallacea fornicatus species complex (Coleoptera: Curculionidae: Scolytinae), are invasive ambrosia beetles that harbor distinct species of Fusarium fungal symbionts.Together with the damage caused by gallery construction, these two phytopathogenic Fusarium species ar

Lead is a heavy metal whose widespread use has resulted in environmental contamination and significant health Building Set problems, particularly if the exposure occurs during developmental stages.It is a cumulative toxicant that affects multiple systems of the body, including the cardiovascular and nervous systems.Chronic lead exposure has been de

Since the recent introduction of several viable vaccines for SARS-CoV-2, vaccination uptake has become the key factor that will determine our success in containing the COVID-19 pandemic.We argue that game theory and social network models should be used to guide decisions pertaining to vaccination programmes for the best possible results.In the mont